Pharmacokinetics of enrofl oxacin in inbred and outbred rabbits

The pharmacokinetics of enrofl oxacin (ENR) were investigated after intravenous (i/v) administration in inbred (n = 10) and outbred (n = 10) healthy rabbits. After i/v ENR injection the elimination half-life (t1/2β), total body clearance (ClB) and the area under the concentration vs. time curve (AUC) in inbred rabbits were 1.51 h, 28.35 ± 1.51 ml/kg/min and 3.01 ± 0.16 μg.h/ml, respectively. The value of t1/2β in outbred rabbits was 2.12 h. The value of ClB (21.47 ± 1.16 ml/kg/min) was signifi cantly lower in outbred rabbits. There were no differences in pharmacokinetic parameters between male outbred and inbred rabbits, and only the value of ClB in female outbred rabbits was signifi cantly lower in comparison to inbred animals. The phenotypic diversity, a manifestation of the complex interaction among the genotype and the environmental factors (the ENR treatment), was clearly less manifested in the inbred group than in outbreds.